Taşınabilinir Esnek Elektrot ile Elektrokimyasal ve Kolorimetrik Laktat Takibi

Abstract

In modern healthcare, particularly for the management of diabetes, the development of non-invasive, cost-effective, and reliable biosensors for glucose monitoring is a critical imperative. Herein, we present a dual-mode glucose biosensor featuring PET-based, screen-printed carbon electrodes supported by laminated Whatman filter paper. Functionalized with glucose oxidase (GOx) and horseradish peroxidase (HRP), the platform enables electrochemical detection via cyclic voltammetry and chronoamperometry, as well as colorimetric analysis through TMB oxidation. In artificial tear samples (0.1–1 mM glucose), the sensor achieved a detection limit (LOD) of 0.3 mM and demonstrated consistent performance across multiple electrodes. Its electrochemical performance (R2=0.99) and reproducibility reflect recent advancements in tear glucose sensing platforms. Given that tear glucose levels typically remain around 0.5 mM, the device is highly suitable for real-time, non-invasive monitoring. Unlike many fluorescence- and nanoparticle-based systems, our device combines simplicity, low cost, and portability, making it exceptionally well-suited for point-of-care and home-use applications. The platform's robust design, reproducible fabrication process, and dual detection methods collectively position it as a promising candidate for non-invasive, user-friendly glucose monitoring in diabetes management. This work represents a significant stride in biosensor technology.